It's actually very common for us, as humans, to look at how small we are in comparison to the rest of the universe and start to feel a little bit insignificant. This isn't even a thing we hide. We hear it spoken about in the media. The irony is, many atheists even use the polar opposite argument I am now to say there can't realistically be a God.
As things go, we are rather insignificant. Even compared to our planet. There are 7 billion people on this earth, and according to World Population Review, nearly 2 of them die every second. By the time you've finished reading this article, (x) people will have died. How many of them can you even name? You see, then, how even with how significant people are to us, their inevitable deaths really don't have that much of an effect. This entire planet could explode tomorrow, not even the other planets in our solar system would miss us.
Yet, God has put eternity into our hearts, and so though we are insignificant in one sense, we know that there are other senses in which we are not. We are insignificant in that the world won't miss us, but we are significant in that, at least for a time, our influence will be missed. We are insignificant in that our deaths are inevitable, but we are significant in that our lives are worth living. We are insignificant in that God can afford to dispose of us, but we are significant in that the Lord still loves us enough to die for us.
This brings with it a number of important thoughts, but these can all be lumped into one: We ought to revere God. We are insignificant to the universe, but the universe is insignificant to God. It can't contain Him, it is contained within Him. Therefore, when He says "obey", we ought to, and when He offers us salvation, there is no greater shame than rejecting it.